PARK2 Antibody

Product Specifications

Background

Parkinson's disease (PD) is a neurodegenerative disease whose symptoms include tremors, rigidity, bradykinesia, and postural instability (1) . Mutations in the PARK2 gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease (2) . The PARK2 protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation (3) . Recent studies have suggested that PARK2 expression reduces the mitochondrial accumulation of the apoptosis protein Bax under basal conditions and directly ubiquitinates Bax, thereby promoting cell survival (4) .

NCBI Gene ID

5071

Swiss Prot

O60260

Accession Number

NP_004553

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Apoptosis

Purification

PARK2 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1362 - Human Cerebellum Tissue Lysate

Concentration

1 mg/mL

Buffer

PARK2 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PARK2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

PARK2 antibody is human specific.

Symbol

PARK2

Positive Control 2

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

Parkin RBR E3 ubiquitin protein ligase

NCBI Organism

Homo sapiens

Background Reference 01

Dauer W and Przedborski S. Parkinson's disease: Mechanisms and models. Neuron 2003; 39:889-909.

Background Reference 02

Kitada T, Asakawa S, Hattori N, et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 1998; 392:605-8.

Background Reference 03

Shimura H, Hattori N, Kubo Si, et al. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat. Genet. 2000; 25:302-5.

Background Reference 04

Johnson BN, Berger AK, Cortese GP, et al. The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax. Proc. Natl. Acad. Sci. USA 2012; 109:6283-88.