HDAC6 Antibody

Product Specifications

Background

The histone deacetylase (HDAC) family contains multiple members which are divided into four classes. Class II of the HDAC family comprises six members, HDAC4, 5, 6, 7, 9 and 10, each of which appear to have tissue-specific roles (1) . HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other (2) . HDAC6 has been shown to be part of the microtubule network and acts as a specific alpha-tubulin deacetylase, and has been suggested to be a potential therapeutic target in neurodegenerative disease (3) .

NCBI Gene ID

10013

Swiss Prot

Q9UBN7

Accession Number

NP_006035

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

HDAC6 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1313 - Human Testis Tissue Lysate

Concentration

1 mg/mL

Buffer

HDAC6 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

HDAC6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

HDAC6 antibody is human and mouse reactive. Multiple isoforms of HDAC6 are known to exist. HDAC6 antibody is predicted to not cross-react with other members of the HDAC family.

Symbol

HDAC6

Positive Control 2

Cat. No. 11-701 - Human Testis Tissue Slide

NCBI Official Name

Histone deacetylase 6

NCBI Organism

Homo sapiens

Background Reference 01

De Ruijter AJ, van Gennip AH, Caron HN, et al. Histone deacetylases (HDACs) : characterization of the classical HDAC family. Biochem. J. 2003; 370:737-49.

Background Reference 02

Grozinger CM, Hassig CA, and Schrieber SL. Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Natl. Acad. Sci. USA 1999; 96:4868-73.

Background Reference 03

Li G, Jiang H, Chang M, et al. HDAC6: a-tubulin decetylase: a potential therapeutic target in neurodegenerative disease. J. Neurol. Sci. 2011; 304:1-8.