PIK3C3 Antibody

Product Specifications

Background

PI 3-kinase p100 (phosphoinositide-3-kinase p100 subunit), also known as hVps34 or PIK3C3 (phosphoinositide-3-kinase class III), is a member of the PI3/PI4-kinase family (1) . It is a catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate and ubiquitously expressed with a highest expression in skeletal muscle (1,2) . PIK3C3 is involved in the endosome to lysosome transport and plays important roles in intracellular membrane trafficking and autophagy (3-5) .

NCBI Gene ID

5289

Swiss Prot

Q8NEB9

Accession Number

NP_002638

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Autophagy

Purification

PIK3C3 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1408 - Mouse Small Intestine Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Pig: (100%)

Buffer

PIK3C3 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PIK3C3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

PIK3C3 antibody is human, mouse and rat reactive.

Symbol

PIK3C3

NCBI Official Name

Phosphatidylinositol 3-kinase, catalytic subunit type 3

NCBI Organism

Homo sapiens

Background Reference 01

Stopkova P, Saito T, Papolos DF, et al. Identification of PIK3C3 promoter variant associated with bipolar disorder and schizophrenia. Biol. Psychiatry 2004; 55:981-8.

Background Reference 02

Hal BS, Gabernet-Castello C, Voak A, et al. TbVps34, the trypanosome orthologue of Vps34, is required for Golgi complex segregation. J. Biol. Chem. 2006; 281:27600-12.

Background Reference 03

Backer JM. The regulation and function of class III PI3Ks: novel roles for Vps34. Biochem. J. 2008; 410:1-17.

Background Reference 04

Jaber N, Dou Z, Lin RZ, et al. Mammalian PIK3C3/VPS34: the key to autophagic processing in liver and heart. Autophagy 2012; 8:707-8.

Other Product Names

PIK3C3 Antibody: VPS34, hVps34, VPS34, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 3-kinase p100 subunit, PI3-kinase type 3