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CRH Antibody

Product Specifications

Background

Corticotropin-releasing hormone (CRH) is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress (1) . In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta where it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturitio (2) . Marked reduction in this protein has been observed in association with Alzheimer disease (3) .

NCBI Gene ID

1392

Swiss Prot

P06850

Accession Number

NP_000747

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis, Neuroscience

Purification

CRH antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1309 - Human Placenta Tissue Lysate

Concentration

1 mg/mL

Buffer

CRH antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

CRH antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=7797

Fragment

IgG

Specificity

CRH antibody is human specific.

Symbol

CRH

Positive Control 2

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

Corticotropin releasing hormone

NCBI Organism

Homo sapiens

Background Reference 01

Maras PM and Baram TZ. Sculpting the hippocampus from within: stress, spines, and CRH. Trends Neurosci. 2012; 315-24.

Background Reference 02

Vrachnis N, Malamas FM, Sifakis S, et al. Immune aspects and myometrial actions of progesterone and CRH in labor. Clin. Dev. Immunol. 2012; 937618.

Background Reference 03

Leake A, Perry EK, Perry RH, et al. Neocortical concentrations of neuropeptides in senile dementia of the Alzheimer and Lewy body type: comparison with Parkinson's disease and severity correlations. Biol. Psychiatry 1991; 29:357-64.

Other Product Names

CRH Antibody: CRF, Corticoliberin, Corticotropin-releasing factor, CRF

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

4503041

Physical Properties

Liquid

Available Sizes

Curated Selection

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