FKBP12 Antibody

Product Specifications

Background

FKBP, or FK506 binding protein, is a family of proteins that have prolyl isomerase activity and are related to the cyclophilins in function (1) . FKBP12, also called FKBP1, was originally identified as a target of FK506 and rapamycin activity and catalyzes the transition between cis and transproline residues critical for proper folding of proteins (2) . FKBP12 is an abundant, evolutionarily conserved cytoplasmic protein that is an important regulator of diverse array of cellular processes including T cell activation, entry into the cell cycle and intracellular calcium release (3-5) .

NCBI Gene ID

2280

Swiss Prot

P62942

Accession Number

NP_463460

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis, Immunology

Purification

FKBP12 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1202 - A431 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Rabbit: (100%)

Buffer

FKBP12 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

FKBP12 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

FKBP12 antibody is human, mouse and rat reactive.

Symbol

FKBP1A

Positive Control 2

Cat. No. 17-002 - A-431 Cell Slide

NCBI Official Name

FK506 binding protein 1A, 12kDa

NCBI Organism

Homo sapiens

Background Reference 01

Siekierka JJ, Hung SH, Poe M, et al. A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature 1989; 341:755-7.

Background Reference 02

Michnick SW, Rosen MK, Wandless TJ, et al. Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin. Science 1991; 252:836-9.

Background Reference 03

Wang T, Donahoe PK, and Zervos AS. Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12. Science 1994; 265:674-6.

Background Reference 04

Wen H, Kang S, Song Y, et al. Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels. Arch. Biochem. Biophys. 2012; 517:37-42.

Other Product Names

FKBP12 Antibody: FKBP1, PKC12, PKCI2, FKBP12, PPIASE, FKBP-12, FKBP-1A, FKBP1, Peptidyl-prolyl cis-trans isomerase FKBP1A, 12 kDa FK506-binding protein, PPIase FKBP1A