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OASL Antibody

Product Specifications

Background

OASL (2'-5'-oligoadenylate synthetase-like), also known as p59OASL or TRIP14 (thyroid receptor-interacting protein 14), is a 514 amino acid protein that exists as two alternatively spliced isoforms, designated p56 and p30, and contains two ubiquitin-like domains (1) . It is widely expressed in a variety of tissues and interacts with the ligand binding domain of the thyroid receptor (TR) and is able to bind double-stranded RNA and DNA, possibly playing a role in RNA degradation and the overall inhibition of protein synthesis (2-3) . Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor (4) .

NCBI Gene ID

8638

Swiss Prot

Q15646

Accession Number

NP_003724

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

OASL antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1410 - Mouse Bladder Tissue Lysate

Concentration

1 mg/mL

Buffer

OASL Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

OASL antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=7775

Fragment

IgG

Specificity

OASL antibody is human, mouse and rat reactive.

Symbol

OASL

Positive Control 2

Cat. No. 17-011 - Hep G2 Cell Slide

NCBI Official Name

2'-5'-oligoadenylate synthetase-like

NCBI Organism

Homo sapiens

Background Reference 01

Rebouillat D, Marie I, and Hovanessian AG. Molecular cloning and characterization of two related and interferon-induced 56 kDa and 30 kDa proteins highly similar to 2'-5' oligoadenylate synthetase. Eur. J. Biochem. 1998; 257:319-30.

Background Reference 02

Hartmann R, Olsen HS, Widder S, et al. p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family. Nucleic Acids Res. 1998; 26:4121-8.

Background Reference 03

Hovnanian A, Rebouillat D, Levy ER, et al. The human 2',5'-oligoadenylate synthetaselike gene (OASL) encoding the interferon-induced 56 kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus. Genomics 1999; 56:362-3.

Background Reference 04

Andersen JB, Strandbygård DJ, Hartmann R, et al. Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1. Eur. J. Biochem. 2004; 271:628-36.

Other Product Names

OASL Antibody: OASLd, TRIP14, TRIP-14, p59OASL, p59 OASL, p59-OASL, Thyroid receptor-interacting protein 14, TR-interacting protein 14

Tested Applications

ELISA, WB, ICC, IF

Protein ID

11321577

Physical Properties

Liquid

Available Sizes

Curated Selection

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