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IFIT3 Antibody

Product Specifications

Background

The interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) protein is a member of a family of tetratricopeptide repeat-containing proteins whose transcription is upregulated by interferons, virus infection, and molecular patterns such as dsRNA or lipopolysaccharides (1,2) . These proteins have been suggested to induce anti-viral cellular activities in response to infection (2) . IFIT3 has been shown to interact with TBK1 following RNA virus infection, thereby bridging TBK1 to VISA on the mitochondrion and activating IRF3 and thus the immune response (3) .

NCBI Gene ID

3437

Swiss Prot

O14879

Accession Number

NP_001026853

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

IFIT3 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1211 - HepG2 Cell Lysate

Concentration

1 mg/mL

Buffer

IFIT3 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

IFIT3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=7759

Fragment

IgG

Specificity

IFIT3 antibody is human specific. This antibody is predicted to not cross-react with other members of the IFIT protein family.

Symbol

IFIT3

Positive Control 2

Cat. No. 10-201 - Human Liver Tissue Slide

NCBI Official Name

Interferon-induced protein with tetratricopeptide repeats 3

NCBI Organism

Homo sapiens

Background Reference 01

Yu M, Tong JH, Mao M, et al. Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulating genes. Proc. Natl. Acad. Sci. USA 1997; 94:7406-11.

Background Reference 02

Fensterl V and Sen GC. The ISG56/IFIT1 gene family. J. Interferon Cytokine Res. 2011; 31:71-8.

Background Reference 03

Raychoudhuri A, Shrivastava S, Steele R, et al. ISG56 and IFITM1 proteins inhibit hepatitis C virus replication. J. Virol. 2011; 85:12881-9.

Other Product Names

IFIT3 Antibody : P60, IRG2, IFI60, IFIT4, ISG60, RIG-G, CIG-49, GARG-49, Interferon-induced protein with tetratricopeptide repeats 3, CIG49, IFIT-3

Tested Applications

ELISA, WB, IHC-P

Protein ID

72534658

Physical Properties

Liquid

Available Sizes

Curated Selection

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