TET1 Antibody

Product Specifications

Background

TET1, a member of the ten-eleven-translocation (TET) family of genes, was initially discovered as a fusion partner of MLL in acute myeloid leukemias containing the t (10;11) (q22; q23) (1) . It is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine (2) . TET1 expression is regulated during inflammation in both THP-1 and primary dendritic cells, and is a negative transcriptional regulator of IL-1beta following and inflammatory stimulus (3) . Recent evidence has shown that TET1 is part of a signaling pathway that regulates breast cancer growth and metastasis (4) .

NCBI Gene ID

80312

Swiss Prot

Q8NFU7

Accession Number

NP_085128

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

7733

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

TET1 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1405 – Mouse Kidney Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (94%), Pig: (88%)

Buffer

TET1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TET1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

TET1 antibody is human, mouse and rat reactive. This antibody is predicted to not cross-react with TET2 and TET3.

Isoform

Human TET1 has one isoform (2136aa, 235kD) . Mouse TET1 has one isoform (2007aa, 219kD) and Rat TET1 also has one isoform (2033aa, 223kD) . 7733 can detect human, mouse and rat.

Symbol

TET1

Positive Control 2

Cat. No. 11-701 - Human Testis Tissue Slide

NCBI Official Name

Tet methylcytosine dioxygenase 1

NCBI Organism

Homo sapiens

Background Reference 01

Lorsbach, et al. Leukemia 2003; 17:637-41.

Background Reference 02

Tahilani , et al. Science 2009; 324:930-5.

Background Reference 03

Neves-Costa, et al. Immunol. 2013; 54:264-70.

Background Reference 04

Sun, et al. Sci. USA 2013; 110:9920-5.

Citation 01

26917720

Other Product Names

TET1 Antibody: LCX, CXXC6, bA119F7.1, KIAA1676, LCX, Methylcytosine dioxygenase TET1, CXXC-type zinc finger protein 6

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

156139122

Physical Properties

Liquid

Available Sizes

Curated Selection

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