CFTR Antibody

Product Specifications

Background

The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a member of the ATP-binding cassette (ABC) transporter superfamily, and a member of the MRP subfamily that is involved in multi-drug resistance (1,2) . CFTR functions as a chloride channel and controls the regulation of other transport pathways (3) . Mutations in this gene are associated with the autosomal recessive disorder cystic fibrosis, the most common, fatal, inherited disease of caucasian populations (1) .

NCBI Gene ID

1080

Swiss Prot

P13569

Accession Number

NP_000483

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

CFTR antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1308 - Human Small Intestine Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Sheep: (100%), Rabbit: (100%), Bovine: (95%), Pig: (89%), Horse: (89%), Guinea pig: (89%)

Buffer

CFTR Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

CFTR antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

CFTR antibody is human, mouse and rat reactive.

Symbol

CFTR

Positive Control 2

Cat. No. 11-801 - Human Small Intestine Tissue Slide

NCBI Official Name

Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

NCBI Organism

Homo sapiens

Background Reference 01

Kerem B, Rommens JM, Buchanan JA, et al. Identification of the cystic fibrosis gene: genetic analysis. Science 1989; 245:1073-80.

Background Reference 02

Harris A and Argent BE. The cystic fibrosis gene and its product CFTR. Semin. Cell Biol. 1993; 4:37-44.

Background Reference 03

Schwiebert EM, Benos DJ, Egan ME, et al. CFTR is a conductance regulator as well as a chloride channel. Physiol. Rev. 1999; 79:S145-66.

Other Product Names

CFTR Antibody: CF, MRP7, ABC35, ABCC7, CFTR/MRP, TNR-CFTR, dJ760C5.1, Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette sub-family C member 7, CFTR