FMR1 Antibody

Product Specifications

Background

Fragile X syndrome is a frequent form of inherited mental retardation caused by functional loss of the fragile X mental retardation protein, FMR1, also known as FMRP (1) . FMR1 binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm (2) . A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome (1) . Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1) (3) .

NCBI Gene ID

2332

Swiss Prot

Q06787

Accession Number

NP_002015

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

FMR1 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1463 - Rat Brain Tissue Lysate

Concentration

1 mg/mL

Buffer

FMR1 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

FMR1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

FMR1 antibody is human, mouse and rat reactive. Multiple isoforms of FMR1 are known to exist.

Symbol

FMR1

Positive Control 2

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

Fragile X mental retardation 1

NCBI Organism

Homo sapiens

Background Reference 01

Jin P and Warren ST. Understanding the molecular basis of fragile X syndrome. Hum. Mol. Genet. 2000; 9:901-8.

Background Reference 02

Corbin F, Bouillon M, Fortin A, et al. The fragile X mental retardation protein is associated with poly (A) + mRNA in actively translating polyribosomes. Hum. Mol. Genet. 1997; 1465-72.