What is the catalog number for PPARGC1A Antibody?

The catalog number for PPARGC1A Antibody is 7705.

What sizes are available for PPARGC1A Antibody?

PPARGC1A Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does PPARGC1A Antibody come in?

PPARGC1A Antibody is available in 2 different pack sizes.

Is PPARGC1A Antibody in stock?

PPARGC1A Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

PPARGC1A Antibody

Product Specifications

Background

The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A), also known as LEM-6, is a transcriptional coactivator that regulates the genes involved in energy metabolism (1) . PPARGC1A interacts with PPARgamma, which permits the interaction of PPARGC1A with multiple transcription factors. PPARGC1A can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs) . It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination (2) . PPARGC1A may be also involved in the development of obesity (3) .

NCBI Gene ID

10891

Swiss Prot

Q9UBK2

Accession Number

NP_037393

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity

Purification

PPARGC1A antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1404 - Mouse Liver Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%)

Buffer

PPARGC1A antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PPARGC1A antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

PPARGC1A antibody is human, mouse and rat reactive. At least three isoforms of PPARGC1A are known to exist; this antibody only detects the longest isoform.

Symbol

PPARGC1A

Positive Control 2

Cat. No. 10-201 - Human Liver Tissue Slide

Positive Control 3

Cat. No. 1304 – Human Liver Tissue Lysate

NCBI Official Name

Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

NCBI Organism

Homo sapiens

Background Reference 01

Tsuemi T and La Spada AR. PGC-1a at the intersection of bioenergetics regulation and neuron function: from Huntington's disease to Parkinson's disease and beyond. Prog. Neurobiol. 2012; 97:142-51.

Background Reference 02

Kang C and Li Ji L. Role of PGC-1a signaling in skeletal muscle health and disease. Ann. NY Acad. Sci. 2012; 1271:110-7.

Background Reference 03

Liu C and Lin JD. PGC-1 coactivators in the control of energy metabolism. Acta Biochim. Biophys. Sin. 2011; 43:248-57.

Other Product Names

PPARGC1A Antibody: LEM6, PGC1, PGC1A, PGC-1v, PPARGC1, PGC-1 (alpha), LEM6, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, Ligand effect modulator 6, PGC-1-alpha