UCP1 Antibody

Product Specifications

Background

The mitochondrial brown fat uncoupling protein 1 (UCP1) is a member of the family of mitochondrial anion carrier proteins (MACP) (1) . UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells (1) . UCP1 is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat (1) .

NCBI Gene ID

7350

Swiss Prot

P25874

Accession Number

NP_068605

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity

Purification

UCP1 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1303 - Human Brain Tissue Lysate

Concentration

1 mg/mL

Buffer

UCP1 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

UCP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

UCP1 antibody is human, mouse and rat reactive.

Symbol

UCP1

Positive Control 2

Cat. No. 10-201 - Human Liver Tissue Slide

NCBI Official Name

Uncoupling protein 1 (mitochondrial, proton carrier)

NCBI Organism

Homo sapiens

Background Reference 01

Rial E, Gonzalez-Barroso MM, Fleury C, et al. The structure and function of the brown fat uncoupling protein UCP1: current status. Biofactors 1998; 8:209-19.