What is the catalog number for TRPV4 Antibody?

The catalog number for TRPV4 Antibody is 7695.

What sizes are available for TRPV4 Antibody?

TRPV4 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does TRPV4 Antibody come in?

TRPV4 Antibody is available in 2 different pack sizes.

Is TRPV4 Antibody in stock?

TRPV4 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

TRPV4 Antibody

Product Specifications

Background

The transient receptor potential (TRP) protein family consists of a diverse group of cation channels functioning in a variety of homeostatic and regulatory pathways. Four subfamilies exist, based on channel domain homology: C type (canonical), V type (vanilloid receptor related), M type (melastatin related) and P type (PKD) (1) . TRPV4, belongs to the V type subfamily and plays a role in systemic osmoregulation (2,3) . TRPV4 is a calcium channel multi-pass membrane protein activated by various stimuli, including thermal stress, fatty acid metabolites and hypotonicity (3) . TRPV4 is highly expressed in lung and kidney and widely expressed in brain. It plays an important role in regulating neural excitability (4) .

NCBI Gene ID

59341

Swiss Prot

Q9HBA0

Accession Number

NP_067638

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

TRPV4 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1220 - SK-N-SH Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Rat: (100%), Mouse: (100%)

Buffer

TRPV4 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TRPV4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

TRPV4 antibody is human specific. At least six isoforms of TRPV4 are known to exist. This antibody is predicted to not cross-react with other TRP protein family members.

Symbol

TRPV4

Positive Control 2

Cat. No. 10-101 - Human Lung Tissue Slide

NCBI Official Name

Transient receptor potential cation channel, subfamily V, member 4

NCBI Organism

Homo sapiens

Background Reference 01

Birnbaumer L, Yildirim E and Abramowitz J. A comparison of the genes coding for canonical TRP channels and their M, V and P relatives. Cell Calcium 2003; 33:419-32.

Background Reference 02

Alessandri-Haber N, Dina OA, Yeh JJ, et al. Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat. J. Neurosci. 2004; 24:4444-52.

Background Reference 03

Liedtke W. TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals. J. Physiol. 2005; 567:53-8.

Background Reference 04

Shibasaki K, Suzuki M, Mizuno A, et al. Effects of body temperature on neural activity in the hippocampus: regulation of resting membrane potentials by transient receptor potential vanilloid 4. J. Neurosci. 2007; 27:1566–75.

Other Product Names

TRPV4 Antibody: SMAL, VRL2, CMT2C, SPSMA, TRP12, VROAC, HMSN2C, OTRPC4, SSQTL1, Transient receptor potential cation channel subfamily V member 4, Osm-9-like TRP channel 4, TrpV4