Puumala Virus Glycoprotein Antibody

Product Specifications

Background

Puumala virus (PUUV) is a rodent-borne hantavirus of the family Bunyaviridae, an enveloped, negative-sense RNA viruses with a tripartite genome that can cause hantavirus pulmonary syndrome (HPS) and is highly homologous to the protype hantavirus Hantaan virus (1) . Like other hantaviruses, the PUUV glycoprotein is synthesized as a precursor that is posttranslationally processed into two glycoproteins G1 (Gn) and G2 (Gc) . These glycoproteins interact with the PUUV nucleocapsid (NP) protein through their cytoplasmic tail, and this association has been suggested to be crucial to the binding of the ribonucleoprotein of the PUUV and the assembly of the virus particle (2) .

NCBI Gene ID

2943082

Swiss Prot

P27312

Accession Number

AFQ60650

Host

Rabbit

Reactivity

Virus

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Infectious Disease

Purification

Puumala virus glycoprotein antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Buffer

Puumala virus glycoprotein antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Puumala virus glycoprotein antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Applications Notes

Puumala virus glycoprotein antibody can detect 10ng Puumala virus glycoprotein peptide in ELISA at 1 μ g/ml.

Symbol

PUUVsMgp1

NCBI Official Name

PUUVsMgp1 glycoprotein polyprotein precursor

NCBI Organism

Puumala virus

Background Reference 01

Vapalahti O, Kallio-Kokko H, Salonen EM, et al. Cloning and sequencing of Puumala virus Sotkamo strain S and M RNA segments: evidence for strain variation in hantaviruses and expression of the nucleocapsid protein. J. Gen. Virol. 1992; 73:829-38.

Background Reference 02

Hepojoki J, Strandin T, Wang H, et al. Cytoplasmic tails of hantavirus glycoproteins interact with the nucleocapsid protein. J. Gen. Virol. 2010; 91:2341-50.