Sin Nombre Virus Nucleocapsid Antibody

Product Specifications

Background

Sin Nombre virus (SNV) is a rodent-borne hantavirus of the family Bunyaviridae, an enveloped, negative-sense RNA viruses with a tripartite genome that can cause hantavirus pulmonary syndrome (HPS) (1) . The hantavirus nucleocapsid protein plays several roles in viral replication and assembly, and is the major antigen in humoral responses in humans and mice (2) . Within the bunyviridae family, the nucleocapsid protein also functions as an RNA chaperone facilitating the formation of the stable genomic RNA “panhandle” and is thought to aid in the replication of bunyavirus RNA (3) .

NCBI Gene ID

2943142

Swiss Prot

Q9E1J8

Accession Number

AAG03030

Host

Rabbit

Reactivity

Virus

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Infectious Disease

Purification

Sin Nombre virus nucleocapsid antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Buffer

Sin Nombre virus nucleocapsid antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Sin Nombre Nucleocapsid antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Applications Notes

Sin Nombre virus nucleocapsid antibody can detect 10ng Sin Nombre virus nucleocapsid peptide in ELISA at 1 μ g/ml.

Symbol

SNVsSgp1

NCBI Official Name

SNVsSgp1 nucleocapsid

NCBI Organism

Sin Nombre virus

Background Reference 01

Spiropoulou CF, Morzunov S, Feldmann H, et al. Genome structure and variability of a virus causing hantavirus pulmonary syndrome. Virology 1994; 200:715-23.

Background Reference 02

Tischler ND, Rosemblatt M, and Valenzuela PD. Characterization of cross-reactive and serotype-specific epitopes on the nucleocapsid proteins of hantaviruses. Virus Res. 2008; 135:1-9.

Background Reference 03

Mir MA and Panganiban AT. The bunyavirus nucleocapsid protein is an RNA chaperone: possible roles in viral RNA panhandle formation and genome replication. RNA 2006; 12:272-82.