Sin Nombre Virus Glycoprotein 1 Antibody

Product Specifications

Background

Sin Nombre virus (SNV) is a rodent-borne hantavirus of the family Bunyaviridae, an enveloped, negative-sense RNA viruses with a tripartite genome that can cause hantavirus pulmonary syndrome (HPS) (1) . Hantavirus glycoprotein precursor (GPC) is posttranslationally cleaved into two glycoproteins G1 (Gn) and G2 (Gc) . The G1 glycoprotein is is thought to be degraded by the host autophagy machinery, and this autophagic clearance is required for efficient virus repliaction (2) .

NCBI Gene ID

2654026

Swiss Prot

Q89905

Accession Number

NP_941974

Host

Rabbit

Reactivity

Virus

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Infectious Disease

Purification

Sin Nombre virus glycoprotein 1 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Buffer

Sin Nombre virus glycoprotein 1 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Sin Nombre Glycoprotein 1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Applications Notes

Sin Nombre virus glycoprotein 1 antibody can detect 10ng Sin Nombre virus glycoprotein 1 peptide in ELISA at 1 μ g/ml.

Symbol

SNVsMgp1

NCBI Official Name

SNVsMgp1 glycoprotein precursor

NCBI Organism

Sin Nombre virus

Background Reference 01

Spiropoulou CF, Morzunov S, Feldmann H, et al. Genome structure and variability of a virus causing hantavirus pulmonary syndrome. Virology 1994; 200:715-23.

Background Reference 02

Hussein ITM, Cheng E, Ganaie SS, et al. Autophagic clearance of Sin Nombre hanatavirus glycoprotein Gn promotes virus replication in cells. J. Virol. 2012; 86:7520-9.