CCR7 Antibody

Product Specifications

Background

The CCR7 protein is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation (1,2) . The chemokine (C-C motif) ligand 19 (CCL19) has been reported to be a specific ligand of this receptor (3) .

NCBI Gene ID

1236

Swiss Prot

P32248

Accession Number

NP_001829

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Chemokines & Cytokines

Purification

CCR7 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1306 - Human Spleen Tissue Lysate

Concentration

1 mg/mL

Buffer

CCR7 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

CCR7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

CCR7 antibody is human specific. CCR7 antibody is predicted to not cross-react with other CCR proteins.

Symbol

CCR7

Positive Control 2

Cat. No. 10-901 - Human Spleen Tissue Slide

NCBI Official Name

Chemokine (C-C motif) receptor 7

NCBI Organism

Homo sapiens

Background Reference 01

Birkenbach M, Josefsen K, Yalamanchil R, et al. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J. Virol. 1993; 67:2209-20.

Background Reference 02

Forster R, Davalos-Misslitz AC, and Rot A. CCR7 and its ligands: balancing immunity and tolerance. Nat. Rev. Immunol. 2008; 8:362-71.

Background Reference 03

Yoshida R, Imai T, Hieshima K, et al. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. J. Biol. Chem. 1997; 272:13803-9.