GRK6 Antibody

Product Specifications

Background

The G protein–coupled receptor kinases (GRKs) are a versatile family of kinases that play a critical role in cancer metastasis through their regulation of G-protein coupled receptors (GPCRs) involved in growth factor mediated cell migration (1,2) . Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state (1) . GRK6 is one of 7 members of the GRK serine/threonine kinase subfamily, which has been shown to modulate the Wnt signaling pathway via phosphorylation of LRP6 (3,4), and the insulin-like growth factor signaling pathway (4) . GRK6 may also play a role in immune system function (5) .

NCBI Gene ID

2870

Swiss Prot

P43250

Accession Number

NP_001004106

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

GRK6 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1468 - Rat Small Intestine Tissue Lysate

Concentration

1 mg/mL

Buffer

GRK6 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

GRK6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

GRK6 antibody is human, mouse and rat reactive. Multiple isoforms of GRK6 are known to exist. This antibody is predicted to not cross-react with other members of the GRK protein family.

Symbol

GRK6

Positive Control 2

Cat. No. 11-801 - Human Small Intestine Tissue Slide

NCBI Official Name

G protein-coupled receptor kinase 6

NCBI Organism

Homo sapiens

Background Reference 01

Inglese J, Freedman NJ, Koch WJ, et al. Structure and mechanism of the G protein-coupled receptor kinases. J. Biol. Chem. 1993; 268:23735-8.

Background Reference 02

Raghuwanshi SK, Smith N, Rivers EJ, et al. G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J. Immunol. 2013; 190:5329-36.

Background Reference 03

Benovic JL and Gomez J. Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family. J. Biol. Chem. 1993; 268:19521-7.