GLIPR1L1 Antibody

Product Specifications

Background

The GLIPR1-like 1 protein (GLIPR1L1) gene is part of a p53 target gene cluster that includes the related proteins GLIPR1 and GLIPR1L2 (1) . GLIPR1L1 is similar to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family (2) . GLIPR1 is a tumor suppressor whose expression is regulated by p53 (3) . Unlike GLIPR1, GLIPR1L1 is expressed primarily in the testis and is thought to be involved in the binding of sperm to the oocyte complex (4) .

NCBI Gene ID

256710

Swiss Prot

Q6UWM5

Accession Number

NP_689992

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

GLIPR1L1 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1313 - Human Testis Tissue Lysate

Concentration

1 mg/mL

Buffer

GLIPR1L1 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

GLIPR1L1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

GLIPR1L1 antibody is human specific. At least two isoforms of GLIPR1L1 are known to exist; this antibody will detect both isoforms. This antibody is predicted to not cross-react with other GLIPR or GLIPR-like proteins.

Symbol

GLIPR1L1

Positive Control 2

Cat. No. 11-701 - Human Testis Tissue Slide

NCBI Official Name

GLI pathogenesis-related 1 like 1

NCBI Organism

Homo sapiens

Background Reference 01

Ren C, Ren CH, Li L, et al. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. Genomics 2006; 88:163-72.

Background Reference 02

Murphy EV, Zhang Y, Zhu W, et al. The human glioma pathogenesis-related protein is structurally related to pathogenesis-related proteins and its gene is expressed specifically in brain tumors. Gene 1995; 159:131-5.

Background Reference 03

Ren C, Li L, Yang G, et al. RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer. Cancer Res. 2004; 64:969-76.

Background Reference 04

Gibbs GM, Lo JC, Nixon B, et al. Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding. Endocrinology 2010; 151:2332-42.