RPSA Antibody

Product Specifications

Background

The 40S ribosomal protein SA (RPSA) is a high-affinity, non-integrin family, laminin receptor, also known as 67 kDa laminin receptor or 37 kDa laminin receptor precursor (37LRP) (1) . Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes and have been implicated in a variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis (2) . RPSA is overexpressed in multiple types of cancers and has recently been shown to act as a cancer-specific death receptor (3) .

NCBI Gene ID

3921

Swiss Prot

P08865

Accession Number

NP_002286

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

RPSA antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1223 - Caco-2 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%), Chicken: (100%), Rat: (100%), Sheep: (100%)

Buffer

RPSA antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

RPSA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

RPSA antibody is human, mouse and rat reactive.

Symbol

RPSA

NCBI Official Name

Ribosomal protein SA

NCBI Organism

Homo sapiens

Background Reference 01

Jackers P, Minoletti F, Belotti D, et al. Isolation from a multigene family of the active human gene of the metastasis-associated 67kDa laminin binding protein 37LRP/p40 at chromosome 3p21.3. Oncogene 1996; 13:495-503.

Background Reference 02

Savino W and Silva-Barbosa SD. Laminin/VLA-6 interactions and T cell function. Braz. J. Med. Biol. Res. 1996; 29:1209-20.

Background Reference 03

Kumazoe M, Sugihara K, Tsukamoto S, et al. 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis. J. Clin. Invest. 2013; 123:787-99.

Other Product Names

RPSA Antibody: SA, LBP, LRP, p40, 67LR, ICAS, lamR, 37LRP, LAMBR, LAMR1, LRP/LR, LBP/p40, NEM/1CHD4, 40S ribosomal protein SA, 37 kDa laminin receptor precursor