CXCL12 Antibody

Product Specifications

Background

The CXCL12 protein, also known as SDF1, is a stromal cell-derived alpha chemokine member of the intercrine family. CXCL12 functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4 (CXCR4) and CXCR7, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis (reviewed in 1) . Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections (2) .

NCBI Gene ID

6387

Swiss Prot

P48061

Accession Number

NP_001171605

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

CXCL12 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1201 - HeLa Cell Lysate

Concentration

1 mg/mL

Buffer

CXCL12 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

CXCL12 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

CXCL12 antibody is human and mouse reactive. Multiple isoforms of CXCL12 are known to exist.

Symbol

CXCL12

Positive Control 2

Cat. No. 17-001 - HeLa Cell Slide

NCBI Official Name

Chemokine (C-X-C motif) ligand 12

NCBI Organism

Homo sapiens

Background Reference 01

Timotijevic G, Mostarica Stojkovic M, and Miljkovic D. CXCL12: role in neuroinflammation. Int. J. Biochem. Cell Biol. 2012; 44:838-41.

Background Reference 02

Reiche EM, Ehara Watanabe MA, Bonametti AM, et al. The effect of stromal cell-derived factor 1 (SDF1/CXCL12) genetic polymorphism on HIV-1 disease progression. Int. J. Mol. Med. 2006; 18:785-93.