COMMD7 Antibody

Product Specifications

Background

COMMD7 (COMM domain-containing protein 7) plays a role in the regulation NF-kappaB (1) . It associates with the NF-kB complex and suppresses its transcriptional activity (2) . COMMD7 contains 1 COMM domain and widely expressed with highest expression in lung (3) . COMMD7 is a newly identified gene overexpressed in hepatocellular carcinoma (HCC) (4) . COMMD7 is associated with tumor invasion and poor prognosis by NF-kappaB signaling pathway (4) .

NCBI Gene ID

149951

Swiss Prot

Q86VX2

Accession Number

NP_444269

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

COMMD7 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1406 - Mouse Spleen Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (95%)

Buffer

COMMD7 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

COMMD7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

COMMD7 antibody is human, mouse and rat reactive. Multiple transcript variants encoding different isoforms have been found for COMMD7.

Symbol

COMMD7

Positive Control 2

Cat. No. 10-901 - Human Spleen Tissue Slide

NCBI Official Name

COMM domain containing 7

NCBI Organism

Homo sapiens

Background Reference 01

Maine GN and Burstein E. COMMD proteins and the control of the NF kappa B pathway. Cell Cycle 2007; 6:672-6.

Background Reference 02

Burstein E, Hoberg JE, Wilkinson AS, et al. COMMD proteins, a novel family of structural and functional homologs of MURR1. J. Biol. Chem. 2005; 280:22222-32.

Background Reference 03

Narindrasorasak S, Kulkarni P, Deschamps P, et al. Characterization and copper binding properties of human COMMD1 (MURR1) . Biochemistry 2007; 46:3116-28.