What is the catalog number for AIMP1 Antibody?

The catalog number for AIMP1 Antibody is 7513.

What sizes are available for AIMP1 Antibody?

AIMP1 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does AIMP1 Antibody come in?

AIMP1 Antibody is available in 2 different pack sizes.

Is AIMP1 Antibody in stock?

AIMP1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

AIMP1 Antibody

Product Specifications

Background

AIMP1 (Endothelial monocyte-activating polypeptide II, EMAP2) is a proinflammatory cytokine for monocytes and granulocytes (1) . It is specifically induced by apoptosis and is involved in the control of angiogenesis, inflammation, and wound healing (1,2) . AIMP1 was identified as one of three auxiliary factors of the mammalian aminoacyl tRNA synthetase (ARS) complex. It binds and facilitates the catalytic reaction of arginyl-tRNA synthetase (2,3) . Recent studies show that CD23 plays an essential role in the AIMP1-induced immune response and might be a target in the treatment of inflammatory diseases (4) .

NCBI Gene ID

9255

Swiss Prot

Q12904

Accession Number

NP_001135888

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

AIMP1 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1463 - Rat Brain Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Chicken: (73%)

Buffer

AIMP1 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

AIMP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

AIMP1 antibody is human, mouse and rat reactive. At least two isoforms of AIMP1 are known to exist; this antibody will recognize both isoforms. AIMP1 antibody is predicted to not cross-react with AIMP2.

Symbol

AIMP1

Positive Control 2

Cat. No. 1303 - Human Brain Tissue Lysate

Positive Control 3

Cat. No. 1403 - Mouse Brain Tissue Lysate

NCBI Official Name

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Park SG, Jung KH, Lee JS, et al. Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase. J. Biol. Chem. 1999; 274:16673–6.

Background Reference 02

Park SG, Shin H, Shin YK, et al. The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair. Am. J. Pathol. 2005; 166:387–98.

Background Reference 03

Quevillon S, Agou F, Robinson JC, et al. The p43 component of the mammalian multi-synthetase complex is likely to be the precursor of the endothelial monocyte-activating polypeptide II cytokine. J. Biol. Chem. 1997; 272:32573–9.

Background Reference 04

Kwon HS, Park MC, Kim DG, et al. Identification of CD23 as a functional receptor for the proinflammatory cytokine AIMP1/p43. J. Cell Sci. 2012; 125:4620-9.

Other Product Names

AIMP1 Antibody: p43, HLD3, EMAP2, SCYE1, EMAPII, Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, Multisynthase complex auxiliary component p43, EMAP-2