IL-1F10 Antibody

Product Specifications

Background

The cytokine IL-1 is responsible for initiating a variety of activities through the activation of transcription factors, NF-kappa B and AP-1, thereby promoting host response to injury or infection (1) . IL-1F10 (Interleukin-1 family member 10), also known as FIL1T, IL1HY2 or FKSG75, is highly expressed in the skin, spleen and proliferating B-cells of the tonsil (2) . IL-1F10 binds soluble IL-1 receptor type 1, and is one of nine Interleukin 1 families clustered on chromosome 2, where it is thought to participate in the regulation of adapted and innate immune responses (3) . IL-1F10 and IL-1RN polymorphisms may play an important role in the susceptibility to developing rheumatoid arthritis (4) .

NCBI Gene ID

84639

Swiss Prot

Q8WWZ1

Accession Number

NP_775184

Host

Rabbit

Reactivity

Human

Immunogen

7503

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Recombinant Protein Test (Figure 1) : Anti- IL-1F10 antibodies (7503) detected human IL-1F10 recombinant protein at different concentrations. Recombinant Protein Test7503

Field of Research

Immunology

Purification

IL-1F10 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1304 - Human Liver Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Mouse (100%) and Rat (88%) .

Buffer

IL-1F10 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

IL-1F10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

IL-1F10 antibody is human, mouse and rat reactive. Two isoforms of IL-1F10 exist.

Isoform

Human IL-1F10 has 2 isoforms, including isoform 1 (152aa, 17kD) and isoform 2 (152aa, 17kD) . Mouse IL-1F10 has one isoform (152aa, 17kD) and Rat IL-1F10 also has one isoform (152aa, 17kD) . 7503 can detect human, mouse and rat.

Symbol

IL1F10

Positive Control 2

Cat. No. 10-901 - Human Spleen Tissue Slide

NCBI Official Name

Interleukin 1 family, member 10 (theta)

NCBI Organism

Homo sapiens

Background Reference 01

Towne et al. J. Biol. Chem. 2004; 279:13677-88.

Background Reference 02

Lin et al. J. Biol. Chem. 2001; 276: 20597-602.

Background Reference 03

Bensen et al. J. Interferon Cytokine Res. 2001; 21:899-904.

Background Reference 04

Cruz-Robles et al. Immunol. Invest. 2009; 38:231-9.

Other Product Names

IL-1F10 Antibody: IL-38, FKSG75, IL1HY2, IL-1HY2, IL1-theta, FIL1-theta, FIL1T, IL38, UNQ6119/PRO20041, Interleukin-1 family member 10, Family of interleukin 1-theta, IL-1F10