IL-1RL2 Antibody

Product Specifications

Background

IL-1RL2 is a member of the interleukin 1 receptor family, but it is incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity (1) . Together with IL-1RAcP, it can bind members of the IL-36 cytokine family, leading to activation of the NF-kappaB pathway (2) . IL-1RL2 can also bind to IL-1F10, resulting in a decreased product of Th17 cytokines in response to immunological or LPS challenge, suggesting that one potential role of IL-1RL2 may be to modulate the immune and inflammation response (3) .

NCBI Gene ID

8808

Swiss Prot

Q9HB29

Accession Number

NP_003845

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

IL-1RL2 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1308 - Human Small Intestine Tissue Lysate

Concentration

1 mg/mL

Buffer

IL-1RL2 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

IL-1RL2 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

IL-1RL2 antibody is human, mouse and rat reactive. At least three isoforms of IL-1RL2 are known to exist; this antibody will detect all three isoforms. IL-1RL2 antibody is predicted to not cross-react with IL-1R or IL-1RL1.

Symbol

IL1RL2

Positive Control 2

Cat. No. 11-801 - Human Small Intestine Tissue Slide

NCBI Official Name

Interleukin 1 receptor-like 2

NCBI Organism

Homo sapiens

Background Reference 01

Lovenberg TW, Crowe PD, Liu C, et al. Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1 1R-rp2) . J. Neuroimmunol. 1996; 70:113-22.

Background Reference 02

Towne JE, Garka KE, Renshaw BR, et al. Interleukin (IL) -1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. J. Biol. Chem. 2004; 279:13677-88.

Background Reference 03

Van de Veerdonk FL, Stoeckman AK, Wu G, et al. IL-38 beinds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist. Proc. Natl. Acad. Sci. USA 2012; 109:3001-5.