What is the catalog number for IL-37 Antibody?

The catalog number for IL-37 Antibody is 7499.

What sizes are available for IL-37 Antibody?

IL-37 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does IL-37 Antibody come in?

IL-37 Antibody is available in 2 different pack sizes.

Is IL-37 Antibody in stock?

IL-37 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

IL-37 Antibody

Product Specifications

Background

Interleukin 37 (IL-37) is a member of the interleukin 1 cytokine family (reviewed in 1) . It can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp) . IL-37 also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18 (1) . IL-37 can also interact with Smad3 and expression of IL-37 in macrophages or epithelial cells resulted in near complete suppression of pro-inflammatory cytokines, suggesting that IL-37 may act as a natural suppressor of the innate inflammatory and immune responses (2,3) .

NCBI Gene ID

27178

Swiss Prot

Q9NZH6

Accession Number

NP_055254

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

IL-37 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1302 - Human Lung Tissue Lysate

Concentration

1 mg/mL

Buffer

IL-37 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

IL-37 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

IL-37 antibody is human specific. Multiple isoforms of IL-37 are known to exist; this antibody will only detect the largest isoform. IL-37 antibody is predicted to not cross-react with IL-36.

Symbol

IL37

Positive Control 2

Cat. No. 10-401 - Human Kidney Tissue Slide

NCBI Official Name

Interleukin 37

NCBI Organism

Homo sapiens

Background Reference 01

Boraschi D, Lucchesi D, Hainzl S, et al. IL-37: a new anti-inflammatory cytokine of the IL-1 family. Eur. Cytokine Netw. 2011; 22:127-47.

Background Reference 02

Nold MF, Nold-Petry CA, Zepp JA, et al. Interleukin 37 is a fundamental inhibitor of innate immunity. Nat. Immunol. 2010; 11:1014-22.

Background Reference 03

Sakai N, Van Sweringen HL, Belizaire RM, et al. Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells. J. Gastroenterol. Hepatol. 2012; 27:1609-16.