IL-12A Antibody

Product Specifications

Background

IL-12A is subunit of the cytokine IL-12 which acts on T- and natural killer cells, and has a broad array of biological activities. IL-12 is a disulfide-linked heterodimer composed of the 35-kD subunit and a 40-kD subunit that is a member of the cytokine receptor family (1) . IL-12 is required for the T-cell-independent induction of interferon (IFN) -gamma, and is important for the differentiation of both Th1 and Th2 cells (1,2) . The responses of lymphocytes to IL-12 are mediated by the activator of transcription protein STAT4 (2) . Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity (3) .

NCBI Gene ID

3592

Swiss Prot

P29459

Accession Number

NP_000873

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Innate Immunity

Purification

IL-12A antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1201 - HeLa Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Llama: (94%), Goat: (89%), Pig: (89%), Sheep: (89%), Horse: (83%), Bovine: (83%)

Buffer

IL-12A antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

IL-12A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

IL-12A antibody is human specific. IL-12A antibody will not cross-react with IL-12B.

Symbol

IL 12A

NCBI Official Name

Interleukin 12A

NCBI Organism

Homo sapiens

Background Reference 01

Gee K, Guzzo C, Che Mat NF, et al. The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. Inflamm. Allergy Drug Targets 2009; 8:40-52.

Background Reference 02

Sinigaglia F, D'Ambrosio D, Panina-Bordignon P, et al. Regulation of the IL-12/IL-12R axis: a critical step in T-helper cell differentiation and effector function. Immunol. Rev. 1999; 170:65-72.

Background Reference 03

Bogdan C, Rollinghoff M, and Diefenbach A. The role of nitric oxide in innate immunity. Immunol. Rev. 2000; 173:17-26.

Other Product Names

Interleukin 12 alpha, p35, natural killer cell stimulatory factor 1, NKSF1, cytotoxic lymphocyte maturation factor 1, CLMF, NF cell stimulatory factor chain 1, NFSK