TMEM107 Antibody

Product Specifications

Background

Transmembrane protein 107 (TMEM 107) is critical for cilia formation and embryonic patterning (1) . It is a 139 amino acid transmembrane protein encoded by a gene that maps to human chromosome 17 which is associated with two key tumor suppressor genes p53 and BRCA1 (1,2) . TMEM107 is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types (1,3) . TMEM107 is also a strong candidate gene for central areolar choroidal dystrophy (CACD) (1-3) .

NCBI Gene ID

84314

Swiss Prot

Q6UX40

Accession Number

NP_115730

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

TMEM107 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1208 - THP-1 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Mouse: (86%), Rat: (86%)

Buffer

TMEM107 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TMEM107antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

TMEM107 antibody is human specific. At least two isoforms of TMEM107 are known to exist.

Symbol

TMEM107

Positive Control 2

Cat. No. 11-521 - Human Lymphoid Tissue Tissue Slide

NCBI Official Name

Transmembrane protein 107

NCBI Organism

Homo sapiens

Background Reference 01

Christopher KJ, Wang B, Kong Y, et al. Forward genetics uncovers transmembrane protein 107 as a novel factor required for ciliogenesis and sonic hedgehog signaling. Dev. Biol. 2012; 368:382-92.

Background Reference 02

Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003; 13:2265-70.