TBX21 Antibody

Product Specifications

Background

TBX21 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box (1,2) . Members of this family include transcription factors involved in the regulation of developmental processes (2) . Studies in mouse and humans show that TBX21 is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (1,3) . Expression of the human ortholog also correlates with interferon-gamma expression in Th1 and natural killer cells, suggesting a TBX21 may play a role in initiating Th1 lineage development from naive Th precursor cells. (3) .

NCBI Gene ID

30009

Swiss Prot

Q9UL17

Accession Number

NP_037483

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

TBX21 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1210 - HEK293 Cell Lysate

Concentration

1 mg/mL

Buffer

TBX21 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TBX21 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

TBX21 antibody is human and mouse reactive.

Symbol

TBX21

Positive Control 2

Cat. No. 17-010 - HEK293 Cell Slide

NCBI Official Name

T-box 21

NCBI Organism

Homo sapiens

Background Reference 01

Szabo SJ, Kim ST, Costa GL, et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100:655-69.

Background Reference 02

Naiche LA, Harrelson Z, Kelly RG, et al. T-box genes in vertebrate development. Annu. Rev. Genet. 2005; 39:219-39.

Background Reference 03

Hibbert L, Pflanz S, De Waal Malefyt R, et al. IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. J. Interfeon Cytokine Res. 2003; 23:513-22.

Other Product Names

TBX21 Antibody : TBET, T-PET, T-bet, TBLYM, TBET, T-box transcription factor TBX21, T-cell-specific T-box transcription factor T-bet, T-box protein 21

Tested Applications

ELISA, WB, IF

Protein ID

7019549

Physical Properties

Liquid

Available Sizes

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