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ARSB Antibody

Product Specifications

Background

Aryl sulfatase B (ARSB) forms a homodimer that hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate (1) . ARSB localizes to the lysozyme as well as to the extracellular matrix (2) . Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B (3), and can be treated with exogenous ARSB (4) .

NCBI Gene ID

411

Swiss Prot

P15848

Accession Number

NP_000037

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

ARSB Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1412 - Mouse Lung Tissue Lysate

Concentration

1 mg/mL

Buffer

ARSB Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

ARSB antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=7465

Fragment

IgG

Specificity

ARSB antibody is human, mouse and rat reactive. At least two isoforms of ARSB are known to exist; this antibody only recognizes the longest isoform.

Symbol

ARSB

Positive Control 2

Cat. No. 1412 - Mouse Cerebellum Tissue Lysate

Positive Control 3

Cat. No. 10-101 - Human Lung Tissue Slide

NCBI Official Name

Arylsulfatase B

NCBI Organism

Homo sapiens

Background Reference 01

Wasserman SI and Austen KF. Arylsulfatase B of human lung. Isolation, characterization, and interaction with slow-reacting substance of anaphylaxis. J. Clin. Invest. 1976; 57:738-44.

Background Reference 02

Mitsunaga-Nakatsubo K, Kusunoki S, Kawakami H, et al. Cell-surface arylsulfatase A and B on sinusoidal endothelial cells, hepatocytes, and Kupffer cells in mammalian livers. Med. Mol. Morphol. 2009; 42:63-9.

Background Reference 03

Valayannopoulos V, Nicely H, Harmatz P, et al. Mucopolysaccharidosis VI. Orphanet. J. Rare Dis. 2010; 5:5.

Background Reference 04

Harmatz P, Whitley CB, Waber L, et al. Enzyme replacement therapy in mucopolysaccharidosis VI (Maroteaux-Lamy syndrome) . J. Pediatr. 2004; 144:574-80.

Other Product Names

ARSB Antibody : ASB, G4S, MPS6, Arylsulfatase B, N-acetylgalactosamine-4-sulfatase, ASB

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

38569405

Physical Properties

Liquid

Available Sizes

Curated Selection

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