What is the catalog number for ARSB Antibody?

The catalog number for ARSB Antibody is 7465.

What sizes are available for ARSB Antibody?

ARSB Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does ARSB Antibody come in?

ARSB Antibody is available in 2 different pack sizes.

Is ARSB Antibody in stock?

ARSB Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

ARSB Antibody

Product Specifications

Background

Aryl sulfatase B (ARSB) forms a homodimer that hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate (1) . ARSB localizes to the lysozyme as well as to the extracellular matrix (2) . Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B (3), and can be treated with exogenous ARSB (4) .

NCBI Gene ID

411

Swiss Prot

P15848

Accession Number

NP_000037

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

ARSB Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1412 - Mouse Lung Tissue Lysate

Concentration

1 mg/mL

Buffer

ARSB Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

ARSB antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

ARSB antibody is human, mouse and rat reactive. At least two isoforms of ARSB are known to exist; this antibody only recognizes the longest isoform.

Symbol

ARSB

Positive Control 2

Cat. No. 1412 - Mouse Cerebellum Tissue Lysate

Positive Control 3

Cat. No. 10-101 - Human Lung Tissue Slide

NCBI Official Name

Arylsulfatase B

NCBI Organism

Homo sapiens

Background Reference 01

Wasserman SI and Austen KF. Arylsulfatase B of human lung. Isolation, characterization, and interaction with slow-reacting substance of anaphylaxis. J. Clin. Invest. 1976; 57:738-44.

Background Reference 02

Mitsunaga-Nakatsubo K, Kusunoki S, Kawakami H, et al. Cell-surface arylsulfatase A and B on sinusoidal endothelial cells, hepatocytes, and Kupffer cells in mammalian livers. Med. Mol. Morphol. 2009; 42:63-9.

Background Reference 03

Valayannopoulos V, Nicely H, Harmatz P, et al. Mucopolysaccharidosis VI. Orphanet. J. Rare Dis. 2010; 5:5.

Background Reference 04

Harmatz P, Whitley CB, Waber L, et al. Enzyme replacement therapy in mucopolysaccharidosis VI (Maroteaux-Lamy syndrome) . J. Pediatr. 2004; 144:574-80.