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FHIT Antibody

Product Specifications

Background

FHIT is member of the histidine triad gene family and is a diadenosine involved in purine metabolism (1) . FHIT is also thought to be a tumor suppressor gene and is involved in multiple apoptotic pathways (1,2) . The FHIT gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene (3) . Aberrant transcripts from this gene have been found in multiple carcinomas (4) .

NCBI Gene ID

2272

Swiss Prot

P49789

Accession Number

NP_002003

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis

Purification

FHIT Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1201 - HeLa Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (88%), Rat: (72%)

Buffer

FHIT Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

FHIT antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=7455

Fragment

IgG

Specificity

FHIT antibody is human and mouse reactive.

Symbol

FHIT

Positive Control 2

Cat. No. 17-001 - HeLa Cell Slide

NCBI Official Name

Fragile histidine triad

NCBI Organism

Homo sapiens

Background Reference 01

Barnes LD, Garrison PN, Siprashvili Z, et al. Fhit, a putative tumor suppressor in humans, is a dinucleotide 5',5'''-P1, P3-triphosphate hydrolase. Biochemistry 1996; 35:11529-35.

Background Reference 02

Wali A. FHIT: doubts are clear now. ScientificWorldJournal 2010; 10:1142-51.

Background Reference 03

Ohta M, Inoue H, Cotticelli MG, et al. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t (3;8) breakpoint, is abnormal in digestive tract cancers. Cell 1996; 84:587-97.

Background Reference 04

Drusco A, Pekarsky Y, Costinean S, et al. Common fragile site tumor suppressor genes and corresponding mouse models of cancer. J. Biomed. Biotechnol.2011; Epub 2010 Dec 29.

Other Product Names

FHIT Antibody : FRA3B, AP3AaseAP3A hydrolase, AP3Aase

Tested Applications

ELISA, WB, IF

Protein ID

4503719

Physical Properties

Liquid

Available Sizes

Curated Selection

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