CEACAM5 Antibody

Product Specifications

Background

CEACAM5 is a member of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily (1,2) . CEACAM proteins are involved in cell-cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation (2) . CEACAM5 has been shown to be overexpressed in a majority of carcinomas and has been suggested to be a intercellular adhesion molecule involved in cancer invasion and metastasis (3) .

NCBI Gene ID

1048

Swiss Prot

P06731

Accession Number

NP_004354

Host

Rabbit

Reactivity

Human, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

CEACAM5 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1462 - Rat Lung Tissue Lysate

Concentration

1 mg/mL

Buffer

CEACAM5 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

CEACAM5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

CEACAM5 antibody is human, mouse and rat reactive. CEACAM5 antibody is predicted to not cross-react with other CEACAM protein family members.

Symbol

CEACAM5

Positive Control 2

Cat. No. 10-101 - Human Lung Tissue Slide

NCBI Official Name

Carcinoembryonic antigen-related cell adhesion molecule 5

NCBI Organism

Homo sapiens

Background Reference 01

Gold P and Freedman SO. Specific carinoembryonic antigens of the human digestive system. J. Exp. Med. 1965; 122:467-81.

Background Reference 02

Kuespert K, Pils S, and Hauck CR. CEACAMs: their role in physiology and pathophysiology. Curr. Opin. Cell Biol. 2006; 565-71.

Background Reference 03

Yoshioka T, Masuko T, Kotanagi H, et al. Homotypic adhesion though carcinoembryonic antigen plays a role in hepatic metastasis development. Jpn. J. Cancer Res. 1998; 89:177-85.