DDC Antibody

Product Specifications

Background

DOPA decarboxylase (DDC) belongs to the group II decarboxylase family of proteins (1) . It is an important protein in the catecholamine biosynthesis pathway. DDC catalyzes the second reaction in the biosynthesis of catecholamines, trace amines and serotonin (1,2) . It can form a homodimer and is expressed in the central nervous system (2) . DDC can be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease, neuroendocrine tumors and drug abuse (3,4) . Defects in DDC gene may cause the autosomal recessive disorder AADC deficiency (4) .

NCBI Gene ID

1644

Swiss Prot

P20711

Accession Number

NP_000781

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

DDC Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1302 - Human Lung Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (92%), Guinea pig: (77%), Pig: (77%)

Buffer

DDC Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

DDC antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

DDC antibody is human, mouse and rat reactive.

Symbol

DDC

Positive Control 2

Cat. No. 10-101 - Human Lung Tissue Slide

NCBI Official Name

Dopa decarboxylase (aromatic L-amino acid decarboxylase)

NCBI Organism

Homo sapiens

Background Reference 01

Berry MD, Juorio AV, Li XM, et al. Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme. Neurochem. Res. 1996; 21:1075-87.

Background Reference 02

Sumi-Ichinose C, Ichinose H, Takahashi E, et al. Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and Serotonin biosynthesis. Biochemistry 1992; 31:2229-38.

Background Reference 03

Haycock JW, Becker L, Ang L, et al. Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum. J. Neurochem. 2003; 87:574-85.