FGFR3 Antibody

Product Specifications

Background

FGFR3 Antibody: FGFR3 is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis (1) . It is required for normal skeleton development and promotes apoptosis in chondrocytes and cancer cell proliferation. FGFR3 protein contains three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain (1,2) . It is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR3 are associated with several diseases, including achondroplasia and hypochondroplasia (3,4) . Mutations in FGFR3 are also a cause of some bladder and cervical cancers (5) .

NCBI Gene ID

2261

Swiss Prot

P22607

Accession Number

NP_001156685

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

FGFR3 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1220 - SK-N-SH Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Chicken: (95%)

Buffer

FGFR3 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

FGFR3 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

Probable post-translational modification

Fragment

IgG

Specificity

FGFR3 antibody is human, mouse and rat reactive. At least three isoforms of FGFR3 are known to exist; this antibody will detect all three.

Symbol

FGFR3

NCBI Official Name

Fibroblast growth factor receptor 3

NCBI Organism

Homo sapiens

Background Reference 01

Keegan K, Johnson DE, and Williams LT. Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3. Proc. Natl. Acad. Sci. USA 1991; 88:1095-9.

Background Reference 02

Turner N and Grose R. Fibroblast growth factor signalling: from development to cancer. Nat. Rev. Cancer 2010; 10:116-29.

Background Reference 03

Superti-Furga A, Eich G, Bucher HU, et al. A glycine 375-to-cysteine substitution in the transmembrane domain of the fibroblast growth factor receptor-3 in a newborn with achondroplasia. Eur. J. Pediatr. 1995; 154:215-9.

Background Reference 04

Bellus GA, McIntosh I, Smith EA, et al. A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia. Nat. Genet. 1995; 10:357-9.