What is the catalog number for TRIM33 Antibody?

The catalog number for TRIM33 Antibody is 7385.

What sizes are available for TRIM33 Antibody?

TRIM33 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does TRIM33 Antibody come in?

TRIM33 Antibody is available in 2 different pack sizes.

Is TRIM33 Antibody in stock?

TRIM33 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

TRIM33 Antibody

Product Specifications

Background

TRIM33 Antibody: TRIM24 (TIF1alpha), TRIM28 (TIF1beta), and TRIM33 (TIF1gamma) are three related cofactors belonging to the tripartite motif superfamily that interact with distinct transcription factors (1-2) . The structure of TRIM33 is similar to TRIM24 and TRIM28, exhibiting multiple domains (RING finger, coiled coil, B boxes, PHD/TTC, and bromodomain) (3) . TRIM33 functions in cell differentiation and development, playing a role in differentiation of hematopoietic cells (3) . It interacts with the Smad2/3 transcription factor in hematopoietic, mesenchymal, and epithelial cell types to mediate different transcriptional effects in response to TGF-beta (4) . It acts as an E3 ubiquitin-protein ligase and promotes SMAD4 ubiquitination (5) .

NCBI Gene ID

51592

Swiss Prot

Q9UPN9

Accession Number

NP_056990

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

TRIM33 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1304 - Human Liver Tissue Lysate

Concentration

1 mg/mL

Buffer

TRIM33 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TRIM33 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

TRIM33 antibody is human, mouse and rat reactive. At least two isoforms of TRIM33 are known to exist.

Symbol

TRIM33

Positive Control 2

Cat. No. 10-201 - Human Liver Tissue Slide

NCBI Official Name

Tripartite motif containing 33

NCBI Organism

Homo sapiens

Background Reference 01

Ransom DG, Bahary N, Niss K, et al. The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS Biol. 2004; 2:E237.

Background Reference 02

Herquel B, Ouararhni K, Khetchoumian K, et al. Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA 2011; 108:8212-7.

Background Reference 03

He W, Dorn DC, Erdjument-Bromage H, et al. Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell 2006; 125:929-41.