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TLX3 Antibody

Product Specifications

Background

TLX3 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL) .

NCBI Gene ID

30012

Swiss Prot

O43711

Accession Number

NP_066305

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

TLX3 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1306 - Human Spleen Tissue Lysate

Concentration

1 mg/mL

Buffer

TLX3 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TLX3 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=7375

Fragment

IgG

Specificity

TLX3 antibody is predicted to not cross-react with other TLX proteins.

Symbol

TLX3

Positive Control 2

Cat. No. 10-901 - Human Spleen Tissue Slide

NCBI Official Name

T-cell leukemia homeobox 3

NCBI Organism

Homo sapiens

Background Reference 01

Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5.

Background Reference 02

Patterson KD and Kried PA. Hox11-family genes XHox11 and XHox11L2 in xenopus: XHoxL2 expression is restricted to a subset of the primary sensory neurons. Dev. Dyn. 1999; 214:34-43.

Background Reference 03

Cheng L, Arata A, Mizuguchi R, et al. Tlx3 and Tlx1 are post-mitotic selector genes determining the glutamatergic over GABAergic cell fates. Nat. Neurosci. 2004; 7:510-7.

Background Reference 04

Cheng L, Samad OA, Xu Y, et al. Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. Nat. Neurosci. 2005; 8:1510-5.

Other Product Names

TLX3 Antibody: RNX, HOX11L2, T-cell leukemia homeobox protein 3, Homeobox protein Hox-11L2

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

50355978

Physical Properties

Liquid

Available Sizes

Curated Selection

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