What is the catalog number for TLX2 Antibody?

The catalog number for TLX2 Antibody is 7373.

What sizes are available for TLX2 Antibody?

TLX2 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does TLX2 Antibody come in?

TLX2 Antibody is available in 2 different pack sizes.

Is TLX2 Antibody in stock?

TLX2 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

TLX2 Antibody

Product Specifications

Background

TLX2 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX2, also known as homeobox11-like 1 (HOX11L1), is a DNA-binding nuclear transcription factor that appears to be crucial for the development of the peripheral nervous system. TLX2 is a downstream target of regulation by both PHOX2A and PHOX2B proteins during intestinal neuronal differentiation. In humans, loss-of-function of TLX2 may play a role in tumorigenesis of gastrointestinal stromal tumors.

NCBI Gene ID

3196

Swiss Prot

O43763

Accession Number

NP_057254

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

TLX2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1463 - Rat Brain Tissue Lysate

Concentration

1 mg/mL

Buffer

TLX2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TLX2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

TLX2 antibody is predicted to not cross-react with other TLX proteins.

Symbol

TLX2

NCBI Official Name

T-cell leukemia homeobox 2

NCBI Organism

Homo sapiens

Background Reference 01

Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5.

Background Reference 02

Puliti A, Cinti R, Betsos N, et al. HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1>p12 and mouse chromosome 6C3-D1. Cytogenet. Cell Genet. 1999; 84:115-7.

Background Reference 03

Borghini S, Di Duca M, Santamaria G, et al. Transcriptional regulation of TLX2 and impaired intestinal innervation: possible role of the PHOX2A and PHOX2B genes. Eur. J. Human Genet. 2007; 15:848-55.

Background Reference 04

Borghini S, Bachetti T, Fava M, et al. The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural crest derived cells. Biochem. J. 2006; 395:355-61.