TLX1 Antibody

Product Specifications

Background

TLX1 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX1, also called homeobox11 (HOX11), as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. TLX1 encodes a homeobox-domain containing protein and is containing a glycine and proline-rich amino terminus. TLX1 is required for maintenance of the developing spleen and cell survival. TLX1 is highly expressed in T-cell leukemia and lymphoid neoplasias as a result of translocation. TLX1-deficient mice have no spleen.

NCBI Gene ID

3195

Swiss Prot

P31314

Accession Number

NP_005512

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

TLX1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1406 - Mouse Spleen Tissue Lysate

Concentration

1 mg/mL

Buffer

TLX1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TLX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

Multiple isoforms of TLX1 exist due to alternative splicing events. TLX1 antibody is predicted to not cross-react with other TLX proteins.

Symbol

TLX1

Positive Control 2

Cat. No. 10-901 - Human Spleen Tissue Slide

NCBI Official Name

T-cell leukemia homeobox 1

NCBI Organism

Homo sapiens

Background Reference 01

Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5.

Background Reference 02

Dube ID, Kamel-Reid S, Yuan CC, et al. A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t (10;14) . Blood 1991; 78:2996-3003.