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DIS3 Antibody

Product Specifications

Background

DIS3 Antibody: The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.

NCBI Gene ID

22894

Swiss Prot

Q9Y2L1

Accession Number

NP_055768

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

DIS3 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1316 - Human Ovary Tissue Lysate

Concentration

1 mg/mL

Buffer

DIS3 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

DIS3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=7343

Fragment

IgG

Specificity

Multiple isoforms of DIS3 are known to exist.

Symbol

DIS3

NCBI Official Name

DIS3 mitotic control homolog (S. cerevisiae)

NCBI Organism

Homo sapiens

Background Reference 01

Chen CY, Gherzi R, Ong SE, et al. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell 2001; 107:451-64.

Background Reference 02

Brouwer R, Allmang C, Raijmakers R, et al. Three novel components of the human exosome. J. Biol. Chem. 2001; 276:6177-84.

Background Reference 03

Schneider C, Anderson JT, Tollervey D, et al. The exosome subunit Rrp44 plays a direct role in RNA substrate recognition. Mol. Cell 2007; 27:324-31.

Background Reference 04

Murakami H, Goto DB, Toda T, et al. Ribonuclease activity of DIS3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function. PLoS ONE 2007; 2:317.

Other Product Names

DIS3 Antibody: RRP44, dis3p, EXOSC11, KIAA1008, 2810028N01Rik, RRP44, Exosome complex exonuclease RRP44, Protein DIS3 homolog

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

190014623

Physical Properties

Liquid

Available Sizes

Curated Selection

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