CRTC2 Antibody

Product Specifications

Background

CRTC2 Antibody: CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB) ) 2 and the related protein CRTC1 are potent CREB coactivators that are exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP. CRTC2 is present in both B and T-lymphocytes and abundantly expressed in the thymus. Its activity is important in regulating the expression of genes involved in cellular energy metabolism while CRTC1 is essential for energy balance and fertility.

NCBI Gene ID

200186

Swiss Prot

Q53ET0

Accession Number

NP_859066

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

CRTC2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1308 - Human Small Intestine Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (94%)

Buffer

CRTC2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

CRTC2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

Multiple isoforms of CRTC2 are known to exist. CRTC2 antibody is predicted to not cross-react with CRTC1.

Symbol

CRTC2

Positive Control 2

Cat. No. 11-801 - Human Small Intestine Tissue Slide

NCBI Official Name

CREB regulated transcription coactivator 2

NCBI Organism

Homo sapiens

Background Reference 01

Conkright MD, Canettieri G, Screaton R, et al. TORCs: transducers of regulated CREB activity. Mol. Cell 2003; 12:413-23.

Background Reference 02

Iourgenko V, Zhang W, Mickanin C, et al. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc. Natl. Acad. Sci. USA 2003; 100:12147-52.

Background Reference 03

Bittinger MA, McWhinnie E, Meltzer J, et al. Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. Curr. Biol. 2004; 14: 2156-61.

Background Reference 04

Jiang S, Inada T, Tanaka M, et al. Involvement of TORC2, a CREB co-activator, in the in vivo-specific transcriptional control of HTLV-1. Retrovirology 2009; 6:73.