Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

KREMEN2 Antibody

Product Specifications

Background

KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.

NCBI Gene ID

79412

Swiss Prot

Q8NCW0

Accession Number

NP_757384

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

7263

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Independent Antibody Validation in Cell lines (Figure 1) shows similar KREMEN2 expression profile in human, mouse and rat cell lines detected by two independent anti-KREMEN2 antibodies that recognize different epitopes, 7263 against C-terminus domain and 64-235 against central domain. KREMEN2 proteins are detected in most of the tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines7263 64-235

Field of Research

Stem Cell

Purification

KREMEN2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1201 - HeLa Cell Lysate

Concentration

1 mg/mL

Buffer

KREMEN2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

KREMEN2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=7263

Fragment

IgG

Specificity

Multiple isoforms of KREMEN2 are known to exist. KREMEN2 antibody is predicted to not cross-react with other Kremen protein family members.

Isoform

Human KREMEN2 has 6 isoforms, including isoform 1 (462aa, 49kD), isoform 2 (424aa, 45kD), isoform 3 (420aa, 44kD), isoform 4 (399aa, 42kD), isoform 5 (423aa, 45kD), and isoform 6 (381aa, 40kD) . Mouse KREMEN2 has one isoform (461aa, 49kD) and rat KREMEN2 also has one isoform (468aa, 50kD) . 7263 can detect human, mouse and rat.

Symbol

KREMEN2

Positive Control 2

Cat. No. 17-001 - HeLa Cell Slide

NCBI Official Name

Kringle containing transmembrane protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Nakamura et al. Biochim. Biophys. Acta. 2001; 1518:63-72.

Background Reference 02

Mao et al. Nature 2002; 417:664-7.

Background Reference 03

Li et al. Fertil. Steril. 2008; 90:1470-9.

Background Reference 04

Schulze et al. PLoS 2010; 5:e10309.

Other Product Names

KREMEN2 Antibody: KRM2, KRM2, Kremen protein 2, Dickkopf receptor 2

Tested Applications

ELISA, WB, ICC

Protein ID

27437008

Physical Properties

Liquid

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Guinea Pig Tumor Necrosis Factor a Receptor ELISA Kit
E05T0027-01 48 Well

Guinea Pig Tumor Necrosis Factor a Receptor ELISA Kit

Ask
View Details
Guinea Pig Tumor Necrosis Factor a Receptor ELISA Kit
E05T0027-02 96 Well

Guinea Pig Tumor Necrosis Factor a Receptor ELISA Kit

Ask
View Details
Human Guanine Deaminase ELISA Kit
IHUGDAKT 1 Each

Human Guanine Deaminase ELISA Kit

Ask
View Details
MST1 (C-Term) Rabbit pAb
MBS8555159-01 0.1 mL

MST1 (C-Term) Rabbit pAb

Ask
View Details
MST1 (C-Term) Rabbit pAb
MBS8555159-02 0.1 mL (AF405L)

MST1 (C-Term) Rabbit pAb

Ask
View Details
MST1 (C-Term) Rabbit pAb
MBS8555159-03 0.1 mL (AF405S)

MST1 (C-Term) Rabbit pAb

Ask
View Details