What is the catalog number for KREMEN1 Antibody?

The catalog number for KREMEN1 Antibody is 7261.

What sizes are available for KREMEN1 Antibody?

KREMEN1 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does KREMEN1 Antibody come in?

KREMEN1 Antibody is available in 2 different pack sizes.

Is KREMEN1 Antibody in stock?

KREMEN1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

KREMEN1 Antibody

Product Specifications

Background

KREMEN1 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) coreceptor. KREMEN1 is a receptor for the Dickkopf protein which blocks Wnt/beta catenin signaling. It is necessary to ensure normal spatial and temporal patterns of Wnt activity during developmental processes.

NCBI Gene ID

83999

Swiss Prot

Q96MU8

Accession Number

NP_114434

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

KREMEN1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1468 - Rat Small Intestine Tissue Lysate

Concentration

1 mg/mL

Buffer

KREMEN1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

KREMEN1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Calculated Molecular Weight

54 kDa

Fragment

IgG

Specificity

Three isoforms of KREMEN1 exists as a result of alternative splicing event.

Symbol

KREMEN1

Positive Control 2

Cat. No. 11-801 - Human Small Intestine Tissue Slide

NCBI Official Name

Kringle containing transmembrane protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Nakamura T, Aoki S, Kitajima K, et al. Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein. Biochim. Biophys. Acta. 2001; 1518:63-72.

Background Reference 02

Mao B, Wu W, Davidson G, et al. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 2002; 417:664-7.

Background Reference 03

Li J, Liu WM, Cao YJ, et al. Roles of Dickkopf-1 and its receptor Kremen1 during embryonic implantation in mice. Fertil. Steril. 2008; 90:1470-9.

Background Reference 04

Wang K, Zhang Y, Li X, et al. Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J. Biol. Chem. 2008; 283:23371-5.