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RC3H1 Antibody

Product Specifications

Background

RC3H1 Antibody: The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.

NCBI Gene ID

149041

Swiss Prot

Q5TC82

Accession Number

NP_742068

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

RC3H1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1201 - HeLa Cell Lysate

Concentration

1 mg/mL

Buffer

RC3H1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

RC3H1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=7251

Calculated Molecular Weight

125 kDa

Fragment

IgG

Specificity

At least three isoforms of RC3H1 are known to exist; this antibody will detect all three isoforms.

Symbol

RC3H1

Positive Control 2

Cat. No. 11-801 - Human Small Intestine Tissue Slide

NCBI Official Name

Ring finger and CCCH-type domains 1

NCBI Organism

Homo sapiens

Background Reference 01

Vinuesa CG, Cook MC, Angelucci C, et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 2005; 435:452-8.

Background Reference 02

Bertossi A, Aichinger M, Sansonetti P, et al. Loss of Roquin induces immune deregulation but not autoimmunity. J. Exp. Med. 2011; 208:1749-56.

Other Product Names

RC3H1 Antibody: RNF198, ROQUIN, KIAA2025, RNF198, Roquin-1, RING finger and C3H zinc finger protein 1, Roquin

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

73695473

Physical Properties

Liquid

Available Sizes

Curated Selection

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