IL-15RA Antibody
Product Specifications
Background
IL-15RA Antibody: Interleukin 15 (IL-15RA) is a cytokine receptor that specifically binds IL-15 with high affinity. IL-15 regulates T and natural killer cell activation and proliferation. The IL-15 and IL-2 receptors share two subunits, IL-2R beta and IL-2R gamma, and IL-15RA is structurally related to IL-2RA, an additional IL-2-specific alpha subunit necessary for high affinity IL-2 binding. Unlike IL-2RA, IL-15RA is capable of binding IL-15 with high affinity independent of the other subunits. IL-15RA is thought to enhance cell proliferation and expression of apoptosis inhibitor Bcl-xL and Bcl-2.
NCBI Gene ID
3601
Swiss Prot
Q13261
Accession Number
NP_001243694
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
IL-15RA Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1468 - Rat Small Intestine Tissue Lysate
Concentration
1 mg/mL
Buffer
IL-15RA Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IL-15RA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=7233
Fragment
IgG
Specificity
Multiple isoforms of IL-15RA are known to exist.
Symbol
IL15RA
NCBI Official Name
Interleukin 15 receptor, alpha
NCBI Organism
Homo sapiens
Background Reference 01
Giri JG, Kumaki S, Ahdieh M, et al. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. 1995; 14:3654-63.
Background Reference 02
Bodnar A, Nizsaloczki E, Mocsar G, et al. A biophysical approach to IL-2 and IL-15 receptor function: localization, conformation and interactions. Immunol. Lett. 2008; 116:117-25.
Background Reference 03
Lorenz HM, Hieronymus T, Grunke M, et al. Differential role for IL-2 and IL-15 in the inhibition of apoptosis in short-term activated human lymphocytes. Scand. J. Immunol. 1997; 45:660-9.
Other Product Names
IL-15RA Antibody: CD215, Interleukin-15 receptor subunit alpha, IL-15 receptor subunit alpha
Tested Applications
ELISA, WB
Protein ID
377520151
Physical Properties
Liquid
Available Sizes
Curated Selection
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