PDGF-B Antibody

Product Specifications

Background

PDGF-B Antibody: The platelet-derived growth factor beta (PDGF-B) is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB) . Mutations in this gene are associated with meningioma , and reciprocal translocations between chromosomes 22 and 7, at sites where the PDGF-B gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans.

NCBI Gene ID

5155

Swiss Prot

P01127

Accession Number

NP_002599

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

PDGF-B Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1464 - Rat Liver Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Sheep: (100%)

Buffer

PDGF-B Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PDGF-B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Calculated Molecular Weight

Predicted: 27 kDa

Fragment

IgG

Symbol

PDGFB

Positive Control 2

Cat. No. 10-201 - Human Liver Tissue Slide

NCBI Official Name

Platelet-derived growth factor beta polypeptid

NCBI Organism

Homo sapiens

Background Reference 01

Johnsson A, Heldin CH, Wasteson A, et al. The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor. EMBO J. 1984; 3:921-8.

Background Reference 02

Fredriksson L, Li H, and Eriksson U. The PDGF family: four gene products for five dimeric isoforms. Cyto. Growth Factor Rev. 2004; 15:197-204.

Background Reference 03

Maxwell M, Galanopoulos T, Hedley-Whyte ET, et al. Human meningiomas co-express platelet-derived growth factor) PDGF) and PDGF-receptor genes and their protein products. Int. J. Cancer 1990; 46:16-21.

Background Reference 04

Simon MP, Navarro M, Roux D, et al. Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t (17;22) (q22; q13.1) in Dermatofibrosarcoma protuberans (DP) . Oncogene 2001; 20:2965-75.