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TPT1 Antibody

Product Specifications

Background

TPT1 Antibody: TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down syndrome.

NCBI Gene ID

7178

Swiss Prot

P13693

Accession Number

NP_003286

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

TPT1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1303 - Human Brain Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Rabbit: (100%), Bovine: (100%), Pig: (100%), Chicken: (74%)

Buffer

TPT1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TPT1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=7193

Calculated Molecular Weight

Predicted: 19 kDa

Fragment

IgG

Symbol

TPT1

NCBI Official Name

Tumor protein, translationally-controlled 1

NCBI Organism

Homo sapiens

Background Reference 01

MacDonald SM, Rafnar T, Langdon J, et al. Molecular identification of an IgE-dependent histamine-releasing factor. Science 1995; 269:688-90.

Background Reference 02

MacDonald SM. Human recombinant histamine-releasing factor. Int. Arch. Allergy Immunol. 1997; 113:187-9.

Background Reference 03

Sanchez JC, Schaller D, Ravier F, et al. Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes. Electrophoresis 1997; 18:150-5.

Background Reference 04

Kuna P and Kaplan AP. Relationship of histamine-releasing factors and histamine-releasing inhibitory factors to chemokine group of cytokine. Allergy Asthma Proc. 1996; 17:5-11.

Other Product Names

TPT1 Antibody: HRF, p02, p23, TCTP, Translationally-controlled tumor protein, Fortilin

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

4507669

Physical Properties

Liquid

Available Sizes

Curated Selection

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