TYK2 Antibody

Product Specifications

Background

TYK2 Antibody: TYK2 is a member of the Janus kinases (JAKs) protein families. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits and is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

NCBI Gene ID

7297

Swiss Prot

P29597

Accession Number

NP_003322

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

TYK2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1308 - Human Small Intestine Tissue Lysate

Concentration

1 mg/mL

Buffer

TYK2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TYK2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Calculated Molecular Weight

Predicted: 131 kDa

Fragment

IgG

Specificity

At least three isoforms of TYK2 are known to exist; this antibody only detects the two longest isoforms.

Symbol

TYK2

NCBI Official Name

Tyrosine kinase 2

NCBI Organism

Homo sapiens

Background Reference 01

Strobl B, Stoiber D, Sexl V, et al. Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity. Front. Biosci. 2011; 17:3214-32.

Other Product Names

TYK2 Antibody: JTK1, Non-receptor tyrosine-protein kinase TYK2

Tested Applications

ELISA, WB, IF

Protein ID

187608615

Physical Properties

Liquid

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

RR212450 10 µg

Best2 (NM_001108895) Rat Tagged ORF Clone

Ask

View Details