CHCHD6 Antibody
Product Specifications
Background
CHCHD6 Antibody: CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1) - (helix 1) - (coiled coil 2) - (helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.
NCBI Gene ID
84303
Swiss Prot
Q9BRQ6
Accession Number
NP_115719
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
CHCHD6 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1220 - SK-N-SH Cell Lysate
Concentration
1 mg/mL
Buffer
CHCHD6 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CHCHD6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=7133
Calculated Molecular Weight
Predicted: 26 kDa
Fragment
IgG
Specificity
CHCHD6 is predicted to not cross-react to other members of the CHCHD family.
Symbol
CHCHD6
NCBI Official Name
Coiled-coil-helix-coiled-coil-helix domain containing 6
NCBI Organism
Homo sapiens
Background Reference 01
Xie J, Marusich MF, Souda P, et al. The mitochondrial inner membrane protein Mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11. FEBS Lett. 2007; 581:3545-9.
Background Reference 02
An J, Shi J, He Q, et al. CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology. J. Biol. Chem. 2012; 287:7411-26.
Other Product Names
CHCHD6 Antibody: CHCM1, PPP1R23, CHCM1, Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial, Coiled coil helix cristae morphology protein 1
Tested Applications
ELISA, WB
Protein ID
14150134
Physical Properties
Liquid
Available Sizes
Curated Selection
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