What is the catalog number for FRL1 Antibody?

The catalog number for FRL1 Antibody is 7101.

What sizes are available for FRL1 Antibody?

FRL1 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does FRL1 Antibody come in?

FRL1 Antibody is available in 2 different pack sizes.

Is FRL1 Antibody in stock?

FRL1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

FRL1 Antibody

Product Specifications

Background

FRL1 Antibody: The Formin-like protein 1 (FRL1) gene encodes a formin-related protein which has been implicated in morphogenesis, cyokinesis, and cell polarity. Formins are a conserved class of proteins expressed in all eukaryotes and have one DAD (diaphanous autoregulatory domain), one FH2 (formin homology 2) domain and one GBD/FH3 (Rho GTPase-binding / formin homology 3) domain. FRL1 is located in the cytoplasm and is highly expressed in the spleen, lymph node and bone marrow cells. FRL1 possibly has a role in the control of cell motility, survival of macrophages and cytoskeletal organization.

NCBI Gene ID

752

Swiss Prot

O95466

Accession Number

NP_005883

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

FRL1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1287 - EL4 Cell Lysate

Concentration

1 mg/mL

Buffer

FRL1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

FRL1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

121 kDa

Fragment

IgG

Specificity

FRL1 antibody is human, mouse and rat reactive. Three alternatively spliced transcript variants have been observed

Symbol

FMNL1

Positive Control 2

Cat. No. 17-207 - EL4 Cell Slide

NCBI Official Name

Formin-like 1

NCBI Organism

Homo sapiens

Background Reference 01

Katoh M and Katoh M. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. Int. J. Oncol. 2003; 22:1161-8.

Background Reference 02

Yayoshi-Yamamoto S, Taniuchi I and Watanabe T. FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages. Mol. Cell. Biol. 2000; 20: 6872-81.

Background Reference 03

Favaro PM, Traina F, Vassallo J, et al. High expression of FMNL1 protein in T non-Hodgkin's lymphomas. Leuk. Res. 2006; 30:735-8.

Background Reference 04

Gomez TS, Kumar K, Medeiros RB, et al. Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. Immunity 2007; 26:177-90.